Hollow Mesoporous Manganese Dioxide Nanoparticles (MnO₂)

Product Overview

Hollow Mesoporous Manganese Dioxide Nanoparticles are manganese oxide materials with internal hollow cavities and mesoporous surfaces. These nanoparticles are synthesized using a hard-template method, where silica nanoparticles are first created via a sol-gel process, followed by the formation of a manganese dioxide shell. The hollow structure is achieved through alkaline etching. This unique structure provides high surface area and excellent biocompatibility, making these nanoparticles highly suitable for biomedical and catalytic applications.

Key Features

• High Surface Area: The hollow structure and large pore volume provide a high surface area, making these nanoparticles ideal for drug delivery and catalysis.
• Excellent Biocompatibility: This material demonstrates superior biocompatibility, making it suitable for in vivo applications in biomedical fields.
• Tumor Microenvironment Responsiveness: Under weakly acidic conditions, these nanoparticles can interact with glutathione (GSH), a metabolic product of cancer cells, to release Mn²⁺, which serves as a magnetic resonance imaging (MRI) contrast agent. Additionally, the nanoparticles catalyze the breakdown of endogenous hydrogen peroxide (H₂O₂) in tumors, enhancing the effectiveness of photodynamic therapy (PDT).
• Multifunctionality: These nanoparticles can be used as drug carriers, catalysts, adsorbents, and electrode materials, offering versatile applications across various fields.

Applications

• Biomedical Field: These nanoparticles serve as efficient drug carriers, precisely delivering anticancer drugs to tumor sites while minimizing toxicity to healthy tissues.
• Photodynamic Therapy (PDT): By breaking down endogenous H₂O₂, these nanoparticles enhance the PDT effect, providing oxygen to promote the action of photosensitizers.
• Electrochemical Catalysis: Due to their high surface area and superior catalytic properties, these nanoparticles are widely used in electrochemical reactions.
• Adsorbents and Catalysts: The high surface area and excellent stability make these nanoparticles highly effective in adsorption and catalytic processes.
• Nanozyme: With catalase-like (CAT) activity, these nanoparticles can decompose H₂O₂ under light exposure, boosting the effectiveness of photodynamic therapy.