{"id":5372,"date":"2025-05-09T10:40:32","date_gmt":"2025-05-09T02:40:32","guid":{"rendered":"https:\/\/www.hi-tech-materials.com\/?post_type=product&#038;p=5372"},"modified":"2025-05-09T10:41:49","modified_gmt":"2025-05-09T02:41:49","slug":"pegylated-ultra-small-fe%e2%82%83o%e2%82%84-nanoparticles-high-temperature-pyrolysis-method","status":"publish","type":"product","link":"https:\/\/www.hi-tech-materials.com\/zh\/product\/pegylated-ultra-small-fe%e2%82%83o%e2%82%84-nanoparticles-high-temperature-pyrolysis-method","title":{"rendered":"PEGylated Ultra-Small Fe\u2083O\u2084 Nanoparticles (High-Temperature Pyrolysis Method)"},"content":{"rendered":"<p><strong>Product Overview<\/strong><br \/>\nPEGylated ultra-small Fe\u2083O\u2084 nanoparticles (synthesized via high-temperature pyrolysis) are iron oxide nanoparticles with an extremely small size (&lt;10 nm), surface-modified with polyethylene glycol (PEG). The PEGylation process enhances their stability, biocompatibility, and circulation time within the biological system, while minimizing non-specific interactions. These nanoparticles exhibit superparamagnetism, making them ideal for magnetic resonance imaging (MRI), magnetic hyperthermia (MHT), drug delivery systems, and multimodal imaging applications.<\/p>\n<p><strong>Key Features<\/strong><\/p>\n<ul>\n<li><strong>Ultra-Small Size<\/strong>: The particle diameter typically ranges from 5-10 nm, improving diffusion capacity and cellular uptake efficiency within the body.<\/li>\n<li><strong>PEGylation<\/strong>: The PEG surface modification enhances nanoparticle stability, biocompatibility, and reduces non-specific interactions with biomolecules.<\/li>\n<li><strong>Synthesis by High-Temperature Pyrolysis<\/strong>: The high-temperature pyrolysis method ensures uniform particle size and excellent crystallinity, which are critical for biomedical applications.<\/li>\n<li><strong>Superparamagnetism<\/strong>: These nanoparticles exhibit superparamagnetic properties, making them suitable for MRI and MHT.<\/li>\n<li><strong>High Biocompatibility<\/strong>: PEG modification improves the compatibility of nanoparticles within biological systems, reducing immune responses and toxicity.<\/li>\n<li><strong>Extended Circulation Time<\/strong>: PEGylation prolongs the nanoparticles&#8217; circulation time in the bloodstream, enhancing targeting and accumulation at diseased sites.<\/li>\n<\/ul>\n<p><strong>Applications<\/strong><\/p>\n<ul>\n<li><strong>Magnetic Resonance Imaging (MRI)<\/strong>: Fe\u2083O\u2084 nanoparticles serve as T2 MRI contrast agents, reducing proton relaxation time to improve image clarity. PEGylation enhances their biocompatibility and tumor-targeting capability, boosting MRI signal strength.<\/li>\n<li><strong>Magnetic Hyperthermia (MHT)<\/strong>: Fe\u2083O\u2084 nanoparticles generate localized heat under an alternating magnetic field, making them useful for tumor treatment. PEG modification increases their accumulation in tumors, enhancing therapeutic effects.<\/li>\n<li><strong>Drug Delivery Systems<\/strong>: PEGylated Fe\u2083O\u2084 nanoparticles act as drug carriers, utilizing the EPR effect for accumulation in tumor tissue, improving targeted drug delivery efficiency.<\/li>\n<li><strong>Multimodal Imaging and Tumor Synergistic Therapy<\/strong>: PEGylated Fe\u2083O\u2084 nanoparticles and their derived composite materials show significant potential in multimodal imaging and tumor synergistic therapy, with enhanced biocompatibility and targeting via surface modifications.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"[tp_attributes num_attributes=\"5\"]\n<div tabindex=\"0\" role=\"article\" data-tabster=\"{&quot;groupper&quot;:{&quot;tabbability&quot;:2},&quot;focusable&quot;:{}}\" data-content=\"ai-message\" aria-labelledby=\"qCjP5C64NhAdgRPyfetDd-author} qCjP5C64NhAdgRPyfetDd-content-0\">\n<div id=\"qCjP5C64NhAdgRPyfetDd-content-0\">\n<p>PEGylated ultra-small Fe\u2083O\u2084 nanoparticles synthesized via high-temperature pyrolysis provide optimized biocompatibility, superior magnetic responsiveness, and enhanced colloidal stability. Designed for advanced biomedical applications, they ensure efficient targeting, extended circulation, and high-performance adaptability.<\/p>\n<\/div>\n<\/div>","protected":false},"featured_media":5373,"comment_status":"open","ping_status":"closed","template":"","meta":{"themepark_post_bcolor":"#f5f5f5","themepark_post_width":"1022px","themepark_post_img":"","themepark_post_img_po":"left","themepark_post_img_re":false,"themepark_post_img_cover":false,"themepark_post_img_fixed":false,"themepark_post_hide_title":false,"themepark_post_main_b":"","themepark_post_main_p":100,"themepark_paddingblock":false},"product_cat":[3723,3698,69],"product_tag":[4005,4154],"class_list":{"0":"post-5372","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-nano-iron-oxide-feo-feo","7":"product_cat-nano-metal-oxides","8":"product_cat-nanomaterials","9":"product_tag-high-performance-biocompatible-nanomaterials","10":"product_tag-pegylated-ultra-small-feo-nanoparticles","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/www.hi-tech-materials.com\/zh\/wp-json\/wp\/v2\/product\/5372","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hi-tech-materials.com\/zh\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/www.hi-tech-materials.com\/zh\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hi-tech-materials.com\/zh\/wp-json\/wp\/v2\/comments?post=5372"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hi-tech-materials.com\/zh\/wp-json\/wp\/v2\/media\/5373"}],"wp:attachment":[{"href":"https:\/\/www.hi-tech-materials.com\/zh\/wp-json\/wp\/v2\/media?parent=5372"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/www.hi-tech-materials.com\/zh\/wp-json\/wp\/v2\/product_cat?post=5372"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/www.hi-tech-materials.com\/zh\/wp-json\/wp\/v2\/product_tag?post=5372"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}