{"id":5129,"date":"2025-05-08T11:22:31","date_gmt":"2025-05-08T03:22:31","guid":{"rendered":"https:\/\/www.hi-tech-materials.com\/?post_type=product&#038;p=5129"},"modified":"2025-05-08T11:23:51","modified_gmt":"2025-05-08T03:23:51","slug":"pei-modified-gold-nanoparticles","status":"publish","type":"product","link":"https:\/\/www.hi-tech-materials.com\/zh\/product\/pei-modified-gold-nanoparticles","title":{"rendered":"PEI-Modified Gold Nanoparticles"},"content":{"rendered":"<p><strong>Product Overview<\/strong><br \/>\nPEI-modified gold nanoparticles are gold nanoparticles further modified with PEI (polyethyleneimine) on top of PEG modification. This modification imparts a positive charge to the nanoparticles, significantly enhancing their potential for biomedical applications, especially in gene delivery, imaging, and targeted drug delivery.<\/p>\n<p><strong>Features<\/strong><\/p>\n<ul>\n<li><strong>Efficient Gene Delivery<\/strong>: PEI-modified gold nanoparticles serve as highly efficient gene carriers, forming complexes with DNA through electrostatic adsorption, which increases gene delivery efficiency.<\/li>\n<li><strong>Excellent Biocompatibility<\/strong>: PEI, a cationic polymer, interacts with cell membranes to improve the binding of nanoparticles to cells, boosting their stability and biocompatibility in biological systems.<\/li>\n<li><strong>Enhanced Optical Properties<\/strong>: The PEI modification further adjusts the optical properties of gold nanoparticles, such as their absorption and scattering characteristics, making them widely applicable in optical imaging and sensing.<\/li>\n<li><strong>Multimodal Imaging Capability<\/strong>: Suitable for MRI (Magnetic Resonance Imaging), photoacoustic imaging, and CT imaging, offering superior imaging performance.<\/li>\n<\/ul>\n<p><strong>Applications<\/strong><\/p>\n<ul>\n<li><strong>Gene and siRNA Delivery<\/strong>: PEI-modified gold nanoparticles act as carriers for genes and siRNA, using RNA interference mechanisms to induce the degradation of target mRNA. They are widely used in gene silencing applications.<\/li>\n<li><strong>Photothermal Therapy<\/strong>: In photothermal therapy, gold nanoparticles convert light energy into heat through surface plasmon resonance, generating localized high temperatures to kill tumor cells. The PEI modification further improves their stability and biocompatibility.<\/li>\n<li><strong>Targeted Drug Delivery<\/strong>: With surface-modified targeting ligands, these nanoparticles can deliver drugs directly to target cells, increasing drug concentration in cancer cells while minimizing toxicity to normal cells.<\/li>\n<li><strong>Radiation Sensitization<\/strong>: Used as radiation sensitizers in cancer treatment, PEI-modified gold nanoparticles enhance the sensitivity of tumor cells to radiation, thereby improving the effectiveness of radiotherapy.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"[tp_attributes num_attributes=\"5\"]\n<div tabindex=\"0\" role=\"article\" data-tabster=\"{&quot;groupper&quot;:{&quot;tabbability&quot;:2},&quot;focusable&quot;:{}}\" data-content=\"ai-message\" aria-labelledby=\"qCjP5C64NhAdgRPyfetDd-author} qCjP5C64NhAdgRPyfetDd-content-0\">\n<div id=\"qCjP5C64NhAdgRPyfetDd-content-0\">\n<p>PEI-modified gold nanoparticles provide optimized surface functionalization, superior colloidal stability, and enhanced biocompatibility. Designed for advanced applications, they ensure efficient dispersion, extended durability, and high-performance adaptability.<\/p>\n<\/div>\n<\/div>","protected":false},"featured_media":5130,"comment_status":"open","ping_status":"closed","template":"","meta":{"themepark_post_bcolor":"#f5f5f5","themepark_post_width":"1022px","themepark_post_img":"","themepark_post_img_po":"left","themepark_post_img_re":false,"themepark_post_img_cover":false,"themepark_post_img_fixed":false,"themepark_post_hide_title":false,"themepark_post_main_b":"","themepark_post_main_p":100,"themepark_paddingblock":false},"product_cat":[3699,3744,69],"product_tag":[3941,3960],"class_list":{"0":"post-5129","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-metallic-nanomaterials","7":"product_cat-nano-gold-au","8":"product_cat-nanomaterials","9":"product_tag-high-performance-biomedical-nanomaterials","10":"product_tag-pei-modified-gold-nanoparticles","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/www.hi-tech-materials.com\/zh\/wp-json\/wp\/v2\/product\/5129","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hi-tech-materials.com\/zh\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/www.hi-tech-materials.com\/zh\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hi-tech-materials.com\/zh\/wp-json\/wp\/v2\/comments?post=5129"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hi-tech-materials.com\/zh\/wp-json\/wp\/v2\/media\/5130"}],"wp:attachment":[{"href":"https:\/\/www.hi-tech-materials.com\/zh\/wp-json\/wp\/v2\/media?parent=5129"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/www.hi-tech-materials.com\/zh\/wp-json\/wp\/v2\/product_cat?post=5129"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/www.hi-tech-materials.com\/zh\/wp-json\/wp\/v2\/product_tag?post=5129"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}