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Carboxylated magnetic microspheres (low nonspecific binding) provide optimized surface functionality, superior biomolecule selectivity, and enhanced magnetic responsiveness. Designed for biomedical and diagnostic applications, they ensure precise molecular interactions, extended durability, and high adaptability.
Product Overview
Carboxylated Magnetic Microspheres (Low Nonspecific Binding) are functionalized magnetic particles with a core-shell structure. The core is composed of polystyrene (PS), while the outer shell is made of magnetite (Fe₃O₄), and the surface is modified with polymeric carboxyl groups. The special chemical treatment minimizes nonspecific adsorption, ensuring high specificity for biomolecular interactions. These microspheres are designed for high-precision biomedical applications, such as cell sorting, affinity chromatography, and immunoassays, where reduced nonspecific binding is essential.
Key Features
- Low Nonspecific Binding: Surface modification with carboxyl groups significantly reduces nonspecific adsorption, ensuring high specificity for biomolecular binding, making them ideal for precise biomedical experiments.
- High Carboxyl Group Density: The surface is rich in carboxyl functional groups, allowing for efficient covalent bonding with biomolecules like peptides, proteins, antibodies, and oligonucleotides.
- Superparamagnetism: The microspheres exhibit superparamagnetism, enabling rapid separation under an external magnetic field, making them convenient for laboratory operations.
- Monodispersity and Stability: The microspheres maintain excellent monodispersity and stability in aqueous solutions, ensuring reproducibility and consistency in experimental results.
Applications
- Biomolecule Separation and Purification: Ideal for affinity chromatography and separation of proteins, nucleic acids, cells, and other biomolecules.
- Immunoprecipitation and Co-immunoprecipitation: Useful for studying protein-protein interactions in research applications.
- Cell Sorting: Magnetic separation based on cell surface markers for cell enrichment and isolation.
- Drug Delivery: Used as components in targeted drug delivery systems, enhancing drug targeting and therapeutic efficiency.
- Biological Detection: Employed in sensors and diagnostic assays for capturing target molecules, enhancing detection sensitivity.
| Item | Parameter |
| Concentration | 10 mg/mL |
| Solvent | Water |
| Particle Size | ~1 μm |
| Surface Carboxyl Content | ~1000 nmol/mg |
| Surface Potential | ~-35 mV |
| Magnetic Content | 35%-45% |
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