Aminated Hollow Prussian Blue Nanoparticles

Product Overview

Aminated Hollow Prussian Blue Nanoparticles are synthesized by reacting potassium ferrocyanide (Fe₄[Fe(CN)₆]₃) with polyvinylpyrrolidone (PVP) and undergoing hydrochloric acid etching to form hollow mesoporous structures. This material demonstrates excellent biocompatibility and safety, making it ideal for applications such as drug delivery, photothermal therapy, and enzyme therapy, especially in tumor treatment. The amination modification enhances its bio-compatibility and targeting ability, enabling it to perform better in the medical field.

Key Features

• Good Dispersion: Due to the amphiphilic nature of PVP, the hollow Prussian Blue nanoparticles exhibit excellent water dispersibility, ensuring uniform distribution in solution.
• High Drug Loading Capacity: The hollow structure offers a large surface area and pore volume, making it an ideal carrier for drugs and genes, improving drug loading efficiency and enabling targeted delivery.
• Multiple Nanocatalytic Activities: The aminated hollow Prussian Blue nanoparticles possess peroxidase (POD), superoxide dismutase (SOD), and catalase (CAT) activities, which help decompose hydrogen peroxide (H₂O₂), generate oxygen or free radicals, and have antioxidant and anti-inflammatory properties.
• Excellent Photothermal Conversion Efficiency: With strong light absorption in the near-infrared region (808 nm), these nanoparticles can convert light energy into heat, facilitating tumor cell ablation and enhancing the activity of nanocatalysts.

Applications

• Drug Loading and Targeted Delivery: Thanks to their hollow structure and amination modification, these nanoparticles can carry chemotherapy drugs for targeted treatment, improving therapeutic effects while reducing damage to healthy cells.
• Photothermal Therapy: The photothermal conversion properties of the hollow Prussian Blue nanoparticles make them promising candidates for tumor ablation in photothermal therapy.
• Nanocatalytic Therapy: With their diverse enzymatic activities, the aminated hollow Prussian Blue nanoparticles can be used to clear free radicals, reduce inflammation, and mitigate oxidative stress, thus alleviating tumor hypoxia.
• Biomedical Imaging: These nanoparticles exhibit strong performance in magnetic resonance imaging (MRI) and photoacoustic imaging (PA), and they can be combined with fluorescence imaging and ultrasound imaging for multi-modal disease diagnosis.