Aminated Prussian Blue Nanoparticles

Product Overview

Aminated Prussian Blue Nanoparticles are nanomaterials based on Prussian Blue (PB), modified with amine groups to enhance their bio-compatibility and targeting ability. This modification broadens the material's application potential, particularly in drug delivery, photothermal therapy, and biomedical imaging. Prussian Blue itself is known for its high biological safety and its use in metal poisoning treatments, and the amination further improves its efficacy in medical applications.

Key Features

• Good Dispersion: Due to the amphiphilic nature of PVP, aminated Prussian Blue nanoparticles exhibit excellent water dispersibility, ensuring uniform distribution in solution.
• Excellent Drug Loading Capability: The hollow structure of the aminated Prussian Blue nanoparticles offers a large surface area and pore volume, making it an ideal drug carrier that can efficiently load and target specific delivery of therapeutic agents.
• Multiple Nanocatalytic Activities: These nanoparticles possess peroxidase (POD), superoxide dismutase (SOD), and catalase (CAT) activities, enabling them to decompose hydrogen peroxide (H₂O₂), generate beneficial free radicals or oxygen, and exhibit antioxidant, anti-inflammatory properties, as well as alleviate tumor hypoxia.
• Excellent Photothermal Conversion Efficiency: With strong absorption in the near-infrared region (808 nm), these nanoparticles can convert light energy into heat, facilitating tumor cell ablation and enhancing the activity of nanocatalysts.

Applications

• Drug Loading and Targeted Delivery: The unique hollow structure of aminated Prussian Blue nanoparticles allows for efficient chemotherapy drug loading and targeted delivery, improving therapeutic outcomes while minimizing side effects on healthy cells.
• Photothermal Therapy: Their excellent light absorption properties make them ideal candidates for photothermal therapy, where near-infrared light is used to efficiently ablate tumor tissue.
• Nanocatalytic Therapy: As nanocatalysts, aminated Prussian Blue nanoparticles can effectively scavenge free radicals, reduce oxidative stress, alleviate inflammation, and aid in tumor treatment.
• Biomedical Imaging: The material demonstrates excellent performance in magnetic resonance imaging (MRI) and photoacoustic imaging (PA), and can be combined with fluorescence imaging and ultrasound imaging for multi-modal diagnostic applications in disease detection.