Reactive Oxygen Species (ROS) Responsive Hydrogel

Product Overview

The ROS-responsive hydrogel is an intelligent material designed to respond to oxidative stress environments within the body. This hydrogel is crosslinked through Polyvinyl Alcohol (PVA) and ROS-sensitive crosslinker (TSPBA), and it undergoes a degradation reaction in the presence of reactive oxygen species (ROS). The material is widely applied in drug-controlled release, tissue engineering, and biosensing.

Key Features

• High Water Absorbency: Combining the water solubility of PVA with the crosslinking capability of TSPBA, this hydrogel retains moisture and maintains softness and elasticity.
• Biocompatibility: PVA is biocompatible with low toxicity, making it suitable for in vivo applications.
• Tunability: By adjusting the ratio of PVA to TSPBA and the polymerization conditions, the mechanical and water absorption properties of the hydrogel can be controlled.
• ROS-sensitive Degradation: In high ROS environments, the boronate ester bonds within the hydrogel oxidize and break down, facilitating controlled drug release.

Applications

• Drug-Controlled Release: Through molecular recognition and responsiveness, the hydrogel enhances drug targeting and therapeutic effects, enabling precise drug delivery.
• Biosensing: By incorporating specific recognition elements, the hydrogel can serve as a biosensor for detecting particular biomolecules.
• Tissue Engineering: As a cell culture matrix or tissue repair material, it promotes cell growth and differentiation.
• Wound Dressing: Combined with antibacterial and antioxidant components, it aids in wound healing and infection prevention.