PEGylated Fe₃O₄ Nanoparticles (Methoxy-Terminated)

Product Overview
PEGylated Fe₃O₄ nanoparticles (Methoxy-Terminated) are synthesized by modifying oleic acid-coated Fe₃O₄ nanoparticles with PEG-methoxy termini using a high-temperature pyrolysis method. This modification allows the nanoparticles to transition from an oil phase to a water phase, significantly expanding their applications in biomedicine, particularly in targeted drug delivery and imaging.

Key Features

• Biocompatibility: The use of biocompatible polyethylene glycol (PEG) enhances the nanoparticles’ biocompatibility, making them suitable for biomedical applications.
• Long Circulation Time: PEG modification increases the blood circulation time of the nanoparticles, improving their passive targeting ability to tumor sites.
• Multifunctionality: The PEG terminus features methoxy, carboxyl, and amino groups, which can be easily conjugated with targeting molecules (such as antibodies, aptamers, or targeting peptides) to construct targeted nanoprobes.
• Stability: PEG modification enhances nanoparticle stability, reduces immune responses, and increases their applicability in biological systems.

Applications

• Drug Delivery System: PEGylated Fe₃O₄ nanoparticles, by increasing stability and circulation time, make ideal drug carriers for targeted drug delivery.
• Magnetic Induction Tumor Hyperthermia (MHT): These nanoparticles can generate heat when exposed to alternating magnetic fields, offering effective treatment for tumors.
• Biosensing and Detection: Due to their magnetic properties, these nanoparticles are widely used in biosensing applications to detect biomolecules or environmental pollutants.
• Nanotheranostics: By combining diagnostic imaging and therapeutic functions, PEGylated Fe₃O₄ nanoparticles can serve as image-guided therapeutic carriers, providing precision medical treatments.