PEI-Modified Gold Nanoparticles

Product Overview
PEI-modified gold nanoparticles are gold nanoparticles further modified with PEI (polyethyleneimine) on top of PEG modification. This modification imparts a positive charge to the nanoparticles, significantly enhancing their potential for biomedical applications, especially in gene delivery, imaging, and targeted drug delivery.

Features

• Efficient Gene Delivery: PEI-modified gold nanoparticles serve as highly efficient gene carriers, forming complexes with DNA through electrostatic adsorption, which increases gene delivery efficiency.
• Excellent Biocompatibility: PEI, a cationic polymer, interacts with cell membranes to improve the binding of nanoparticles to cells, boosting their stability and biocompatibility in biological systems.
• Enhanced Optical Properties: The PEI modification further adjusts the optical properties of gold nanoparticles, such as their absorption and scattering characteristics, making them widely applicable in optical imaging and sensing.
• Multimodal Imaging Capability: Suitable for MRI (Magnetic Resonance Imaging), photoacoustic imaging, and CT imaging, offering superior imaging performance.

Applications

• Gene and siRNA Delivery: PEI-modified gold nanoparticles act as carriers for genes and siRNA, using RNA interference mechanisms to induce the degradation of target mRNA. They are widely used in gene silencing applications.
• Photothermal Therapy: In photothermal therapy, gold nanoparticles convert light energy into heat through surface plasmon resonance, generating localized high temperatures to kill tumor cells. The PEI modification further improves their stability and biocompatibility.
• Targeted Drug Delivery: With surface-modified targeting ligands, these nanoparticles can deliver drugs directly to target cells, increasing drug concentration in cancer cells while minimizing toxicity to normal cells.
• Radiation Sensitization: Used as radiation sensitizers in cancer treatment, PEI-modified gold nanoparticles enhance the sensitivity of tumor cells to radiation, thereby improving the effectiveness of radiotherapy.